团队已制定明确的研究计划并已有前期基础，欢迎有兴趣者进一步交流细节和方法。
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肾脏纤维化中的损伤型细胞态多样性、代谢调控和临床靶点
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人类肾脏疾病异质性、肾脏损伤修复中的分子机制和转化研究
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单细胞/空间多组学技术和生物信息技术的开发和人工智能应用
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人类健康与疾病中的基因组、表观组和其它遗传因子的高通量研究
实验室鼓励学科交叉和学科融合，旨在让热爱科学的成员接受扎实的科研训练，掌握全面的科学知识和技能，学习最前沿的空间组学、单细胞组学、分子代谢等生物技术。
实验室将帮助成员取长补短、高效获得科研产出，培养成员优秀的科研素养和正直的职业品德，全力支持每个人的职业发展，使其未来成为技能全面、能够独当一面的独立科研工作者。
我们正在积极组建具有优秀科学潜力和合作精神的研究团队（包括助理研究员、博士后、技术员和博士研究生），欢迎有意向的同学、青年才俊以及合作者联系。有意加入者请将简历发至邮箱[haikuolibio@gmail.com]，并简要介绍科研经历和技能。
About PI:
Dr. Li obtained B.S. in bioscience from Shanghai Jiao Tong University (Zhiyuan Honors Program) and Ph.D. in molecular genetics and genomics from Washington University in St. Louis. He was a postdoctoral research associate at Yale University Department of Biomedical Engineering.
His research explores mechanisms of kidney injury, fibrosis and metabolic dysregulation with single-cell and spatial omics approaches, including single-cell transcriptomics, chromatin accessibility and spatially resolved multiomics. In addition, he is broadly interested in epigenetic regulation of gene expression in human diseases, as well as development of cutting-edge genomics technologies.
Since 2020, he has published 9 first-author research articles in journals such as Cell Metabolism, Nature Protocols and Scientific Data, and 6 first-author reviews in Nature Immunology, The Journal of Clinical Investigation and Kidney International. In Cell Metabolism 2022, Li et al. identified novel cell states of injured proximal tubules and dysregulated lipid metabolism in mouse models of kidney fibrosis, featured in the 2023 NIDDK annual report. In Cell Metabolism 2024, Li et al. developed a single-cell multiomics atlas for human kidneys, uncovering region-specific signatures. His work advances understanding of kidney injury and repair mechanisms and development of high-throughput genomics methods. Since 2023, he has been invited as a peer reviewer by reputable journals including Nature, Journal of the American Society of Nephrology, Kidney International, Nature Communications, and Genomics, Proteomics & Bioinformatics for over 20 times.